Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc3.3 | Diabetes and obesity | ECE2008

Regulation of lipolysis by corticotropin releasing hormone in brown adipocytes

Markovic Danijela , Digby Janet E , Lehnert Hendrik , Pessin Jeffery , Grammatopoulos Dimitris K

Corticotropin releasing hormone (CRH) and its related peptides, urocortins (UCN), are now emerging as critical regulators of energy balance and homeostasis. These peptides exert their effects through activation of two types of CRH receptors (CRH-R1 and CRH-R2). The role of these peptides as regulators of mammalian thermogenesis and their effects on brown adipose tissue (BAT) have been primarily attributed to modulation of brain centres controlling sympathetic outflow. However,...